Inhibition of miR-9 decreases osteosarcoma cell proliferation
نویسندگان
چکیده
منابع مشابه
Mir-55 inhibition can reduce cell proliferation and induce apoptosis in Jurkat (Acute T cell Leukemia) cell line
Background MicroRNAs are small and non-coding RNA molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mRNA. MiR-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. One of its best known functions is apoptosis that affects on caspase-3 activity. The main aim...
متن کاملMiR-374a promotes the proliferation of osteosarcoma cell proliferation by targeting Axin2.
BACKGROUND MicroRNA-374a (miR-374a) has been implicated in several cancers. However, its role in osteosarcoma (OS) remains unclear. Thus the aim of this study was to investigate its expression and role in progression of OS. METHODS Quantitative real-time PCR (qRT-PCR) was performed to detect the expression of miR-374a in OS cell lines and tissues. To further understand its role, we restored e...
متن کاملmir-55 inhibition can reduce cell proliferation and induce apoptosis in jurkat (acute t cell leukemia) cell line
background micrornas are small and non-coding rna molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mrna. mir-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. one of its best known functions is apoptosis that affects on caspase-3 activity. the main aim ...
متن کاملmiR-422a inhibits osteosarcoma proliferation by targeting BCL2L2 and KRAS
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. However, the underlying mechanism of osteosarcoma carcinogenesis and progression remains unknown. In the present study, we evaluated the expression profile of miRNAs in osteosarcoma tissues and the adjacent normal tissues. We found that the expression of miR-422a was down-regulated in osteosarcoma tissues ...
متن کاملmiR-494 inhibits cell proliferation and metastasis via targeting of CDK6 in osteosarcoma
Tumorigenesis is a multistep process involving various cell growth‑associated factors. Accumulated evidence indicates that the disordered regulation of microRNAs (miRNAs) contributes to tumorigenesis. However, the detailed mechanism underlying the involvement of miRNAs in oncogenesis remains to be fully elucidated. In the present study, the repressed expression of microRNA (miR)‑494 was identif...
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ژورنال
عنوان ژورنال: Bosnian Journal of Basic Medical Sciences
سال: 2019
ISSN: 1840-4812,1512-8601
DOI: 10.17305/bjbms.2019.4434